Metavac-RSV mucosal bivalent vaccine candidate protects cotton rats against pneumoviruses and is produced using serum-free cell culture in bioreactor

Metavac-RSV mucosal bivalent vaccine candidate protects cotton rats against pneumoviruses and is produced using serum-free cell culture in bioreactor

Abstract Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are the main etiologic agents of viral bronchiolitis and pneumonia in children and the elderly. As live-attenuated vaccines (LAV) can stimulate robust mucosal and cellular responses, we previously engineered an HMPV-based bi...

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Main Authors: Caroline Chupin, Pauline Brun, Marjorie Ray, Chloé Mialon, Maëlle Reitano, Aurélien Traversier, Emilie Laurent, Abdelghafar Goumaidi, Julien Fouret, Stéphane Paul, Marina Boukhvalova, Kevin Yim, Jorge Blanco, Marie-Eve Hamelin, Guy Boivin, Manuel Rosa-Calatrava, Julia Dubois
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01231-9
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https://doi.org/10.1038/s41541-025-01231-9

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