Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques

Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques

A vaccine is considered essential for controlling the HIV pandemic and ultimately eradicating AIDS. Neutralizing antibodies and MHC-E-restricted CD8+ T cells have shown the ability to protect against the simian counterpart of HIV, SIV, in rhesus macaques. In this study, we provide preliminary eviden...

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Bibliographic Details
Main Authors: Jessica Coppola, Mara Parren, Raiza Bastidas, Karen Saye, Jacqueline Malvin, Joseph G. Jardine, Roxanne M. Gilbride, Sohita Ojha, Shana Feltham, David Morrow, Aaron Barber-Axthelm, Rachele Bochart, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Jeffrey D. Lifson, Louis J. Picker, Dennis R. Burton, Scott G. Hansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
HIV
SIV
neutralizing antibodies
T cells
vaccine
non-human primate (macaque)
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1592647/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1592647/full

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