Concise Synthesis of Naphthalene-Based 14-Aza-12-Oxasteroids

Concise Synthesis of Naphthalene-Based 14-Aza-12-Oxasteroids

A concise, transition metal-free four-step synthetic pathway has been developed for the synthesis of tetracyclic heterosteroidal compounds, 14-aza-12-oxasteroids, starting from readily available 2-naphthol analogues. After conversion of 2-naphthols to 2-naphthylamines by the Bucherer reaction, subse...

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Bibliographic Details
Main Authors: Smriti Srivastava, Jun Luo, Daniel Whalen, Katherine N. Robertson, Amitabh Jha
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
heterosteroids
14-aza-12-oxosteroid
Sugasawa reaction
Dean–Stark condensation
double dehydration
Online Access:https://www.mdpi.com/1420-3049/30/2/415
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