TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection

TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection

BackgroundAlveolar echinococcosis (AE), a severe zoonotic disease predominantly endemic to pastoral regions, is characterized by hepatic parasitic lesions caused by Echinococcus multilocularis.MethodsThis study investigated the role of T-cell immunoglobulin and mucin domain-4 (TIMD4/Tim-4) in patien...

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Bibliographic Details
Main Authors: Liang Wang, Yumei Liu, Yuyu Ma, Xuan Zhou, Maidinaimu Aibibula, Xue Zhang, Hui Zhao, Jinping Zhou, Fengming Tian, Xiumin Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Echinococcus multilocularis
Tim-4
parasite infection
immunity
macrophage
liver fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1600686/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1600686/full

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