Predicting CTCF cell type active binding sites in human genome

Predicting CTCF cell type active binding sites in human genome

Abstract The CCCTC-binding factor (CTCF) is pivotal in orchestrating diverse biological functions across the human genome, yet the mechanisms driving its cell type-active DNA binding affinity remain underexplored. Here, we collected ChIP-seq data from 67 cell lines in ENCODE, constructed a unique da...

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Bibliographic Details
Main Authors: Lu Chai, Jie Gao, Zihan Li, Hao Sun, Junjie Liu, Yong Wang, Lirong Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
CTCF binding site
Convolutional neural networks
Chromatin accessibility
RAD21
SMC3
Online Access:https://doi.org/10.1038/s41598-024-82238-5
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https://doi.org/10.1038/s41598-024-82238-5

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