Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minimal hepatic encephalopathy

Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minimal hepatic encephalopathy

Abstract Background Patients with steatotic liver disease may show mild cognitive impairment. Rats with mild liver damage reproduce this cognitive impairment, which is mediated by neuroinflammation that alters glutamate neurotransmission in the hippocampus. Treatment with extracellular vesicles (EV)...

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Bibliographic Details
Main Authors: Gergana Mincheva, Victoria Moreno-Manzano, Vicente Felipo, Marta Llansola
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Stem Cell Research & Therapy
Subjects:
Mild liver damage
Extracellular vesicles
TGFβ
Cognitive impairment
Glial activation
GABA and glutamate receptors
Online Access:https://doi.org/10.1186/s13287-024-04076-6
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