Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma
The aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP—ferric reducing ability of plasma, and reduced glutathione—GSH) and enzymatic (glutathione pe...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2011/206316 |
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| author | R. Francik M. Krosniak M. Barlik A. Kudla R. Grybos T. Librowski |
| author_facet | R. Francik M. Krosniak M. Barlik A. Kudla R. Grybos T. Librowski |
| author_sort | R. Francik |
| collection | DOAJ |
| description | The aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP—ferric reducing ability of plasma, and reduced glutathione—GSH) and enzymatic (glutathione peroxidase—GPx, catalase—CAT, and GPx/CAT ratio) activity in the plasma of healthy male Wistar rats. Three vanadium complexes: [VO(bpy)2]SO4⋅2H2O, [VO(4,4′Me2bpy)2]SO4⋅2H2O, and Na[VO(O2)2(bpy)]⋅8H2O are administered by gavage during 5 weeks in two different diets such as control (C) and high fatty (F) diets. Changes of biochemical and antioxidants parameters are measured in plasma. All three vanadium complexes statistically decrease the body mass growth in comparison to the control and fatty diet. In plasma GSH was statistically increased in all vanadium complexes-treated rats from control and fatty group in comparison to only control group. Calculated GPX/CAT ratio was the highest in the control group in comparison to others. |
| format | Article |
| id | doaj-art-2f70a9c8c18e4b7d819bcc5601cd4f92 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-2f70a9c8c18e4b7d819bcc5601cd4f922025-02-03T01:00:26ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2011-01-01201110.1155/2011/206316206316Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats PlasmaR. Francik0M. Krosniak1M. Barlik2A. Kudla3R. Grybos4T. Librowski5Department of Bioorganic Chemistry, Medical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, PolandDepartment of Food Chemistry and Nutrition, Medical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, PolandMedical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, PolandMedical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, PolandFaculty of Chemistry, Jagiellonian University, 9 Ingardena Street, Krakow, PolandDepartment of Pharmacodynamics, Medical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, PolandThe aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP—ferric reducing ability of plasma, and reduced glutathione—GSH) and enzymatic (glutathione peroxidase—GPx, catalase—CAT, and GPx/CAT ratio) activity in the plasma of healthy male Wistar rats. Three vanadium complexes: [VO(bpy)2]SO4⋅2H2O, [VO(4,4′Me2bpy)2]SO4⋅2H2O, and Na[VO(O2)2(bpy)]⋅8H2O are administered by gavage during 5 weeks in two different diets such as control (C) and high fatty (F) diets. Changes of biochemical and antioxidants parameters are measured in plasma. All three vanadium complexes statistically decrease the body mass growth in comparison to the control and fatty diet. In plasma GSH was statistically increased in all vanadium complexes-treated rats from control and fatty group in comparison to only control group. Calculated GPX/CAT ratio was the highest in the control group in comparison to others.http://dx.doi.org/10.1155/2011/206316 |
| spellingShingle | R. Francik M. Krosniak M. Barlik A. Kudla R. Grybos T. Librowski Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma Bioinorganic Chemistry and Applications |
| title | Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma |
| title_full | Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma |
| title_fullStr | Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma |
| title_full_unstemmed | Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma |
| title_short | Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma |
| title_sort | impact of vanadium complexes treatment on the oxidative stress factors in wistar rats plasma |
| url | http://dx.doi.org/10.1155/2011/206316 |
| work_keys_str_mv | AT rfrancik impactofvanadiumcomplexestreatmentontheoxidativestressfactorsinwistarratsplasma AT mkrosniak impactofvanadiumcomplexestreatmentontheoxidativestressfactorsinwistarratsplasma AT mbarlik impactofvanadiumcomplexestreatmentontheoxidativestressfactorsinwistarratsplasma AT akudla impactofvanadiumcomplexestreatmentontheoxidativestressfactorsinwistarratsplasma AT rgrybos impactofvanadiumcomplexestreatmentontheoxidativestressfactorsinwistarratsplasma AT tlibrowski impactofvanadiumcomplexestreatmentontheoxidativestressfactorsinwistarratsplasma |