Network Medicine‐Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD‐L1 Expression via Targeting SPOP in Cancer

Network Medicine‐Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD‐L1 Expression via Targeting SPOP in Cancer

Abstract Immune checkpoint inhibitors (ICIs) are drugs that inhibit immune checkpoint (ICP) molecules to restore the antitumor activity of immune cells and eliminate tumor cells. Due to the limitations and certain side effects of current ICIs, such as programmed death protein‐1, programmed cell deat...

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Main Authors: Saisai Tian, Mengting Xu, Xiangxin Geng, Jiansong Fang, Hanchen Xu, Xinying Xue, Hongmei Hu, Qing Zhang, Dianping Yu, Mengmeng Guo, Hongwei Zhang, Jinyuan Lu, Chengyang Guo, Qun Wang, Sanhong Liu, Weidong Zhang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
colorectal cancer
immune checkpoint inhibitors
lung cancer
maprotiline
Mnet‐DRI
PD‐L1
Online Access:https://doi.org/10.1002/advs.202410285
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https://doi.org/10.1002/advs.202410285

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