Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine

Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine

Abstract Background The offset analgesia phenomenon refers to the disproportionately large decrease in the perceived pain following a slight decrease in intensity of a noxious heat stimulus. It is considered an expression of the activation of the endogenous pain-modulation system. The main aim of th...

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Bibliographic Details
Main Authors: Giuseppe Cosentino, Elisa Antoniazzi, Camilla Cavigioli, Elena Guaschino, Natascia Ghiotto, Matteo Castaldo, Massimiliano Todisco, Roberto De Icco, Cristina Tassorelli
Format: Article
Language:English
Published: BMC 2025-03-01
Series:The Journal of Headache and Pain
Subjects:
Pathophysiology of migraine
Descending pain control system
Dynamic nociceptive stimulation
Offset analgesia
Rostral ventromedial medulla
Migraine chronification
Online Access:https://doi.org/10.1186/s10194-025-01995-4
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https://doi.org/10.1186/s10194-025-01995-4

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