Regional and Gender-Based Distribution of KRAS Mutations in Metastatic Colorectal Cancer Patients in Turkey: An Observational Study

Regional and Gender-Based Distribution of KRAS Mutations in Metastatic Colorectal Cancer Patients in Turkey: An Observational Study

<i>Background and Objectives:</i> KRAS genes are among the most prominent oncogenes that trigger tumor formation in colorectal cancer (CRC) and serve as predictive biomarkers for resistance to anti-EGFR therapies in metastatic colorectal cancer (mCRC) patients. However, the prevalence an...

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Main Authors: Nurullah Ilhan, Faysal Dane, Erdem Goker, Kazım Uygun, Bülent Orhan, Kerem Okutur, İlkay Tuğba Ünek, Abdurrahman Işıkdoğan, Ahmet Bilici, Nurullah Zengin, Necati Alkış, İdris Yücel, Hatice Odabaş, Berna Ömür Öksüzoğlu, Akif Doğan, Hande Nur Erölmez, Mahmut Gümüş
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Medicina
Subjects:
KRAS mutation
metastatic colorectal cancer
anti-EGFR resistance
predictive biomarkers
codon 12 mutation
codon 13 mutation
Online Access:https://www.mdpi.com/1648-9144/61/4/694
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