Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity

Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity

Abstract Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinical challenges. This study compared various LNP formulations for delivering DNA-encoded biologics, assessing their expression efficacy and the protective immunity generat...

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Bibliographic Details
Main Authors: Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Cancer
Subjects:
Lipid nanoparticles
DNA-encoded biologics
Vaccines
Monoclonal antibodies
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12943-024-02211-8
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https://doi.org/10.1186/s12943-024-02211-8

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