Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression

Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression

Objective To demonstrate the significance of supercharged natural killer (sNK) cells to target aggressive gynecological tumours.Methods and analysis We used cell cultures of peripheral blood-derived mononuclear cells (PBMCs) and purified NK cells alone and in the presence of tumours. MHC-class gene...

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Main Authors: Sara Huerta-Yepez, Thomas G Graeber, Neda A Moatamed, Po-Chun Chen, Sanaz Memarzadeh, Subramaniam Malarkannan, Ao Mei, Kawaljit Kaur, Yash Jain, Tanya Singh, Favour Esedebe, Yi Jou Liao, Gabriella DiBernardo, Anahid Jewett
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:BMJ Oncology
Online Access:https://bmjoncology.bmj.com/content/4/1/e000618.full
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https://bmjoncology.bmj.com/content/4/1/e000618.full

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