Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature
Background. Aseptic abscesses (AA) are sterile lesions that represent an extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Though Canada has the highest prevalence of IBD in the world, reports of IBD-associated AA are absent in Canada. This may represent a different IBD phenot...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/5124354 |
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| author | Natasha Bollegala Rishad Khan Michael A. Scaffidi Ahmed Al-Mazroui Jenna Tessolini Adrienne Showler Errol Colak Samir C. Grover |
| author_facet | Natasha Bollegala Rishad Khan Michael A. Scaffidi Ahmed Al-Mazroui Jenna Tessolini Adrienne Showler Errol Colak Samir C. Grover |
| author_sort | Natasha Bollegala |
| collection | DOAJ |
| description | Background. Aseptic abscesses (AA) are sterile lesions that represent an extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Though Canada has the highest prevalence of IBD in the world, reports of IBD-associated AA are absent in Canada. This may represent a different IBD phenotype or underrecognition and underreporting. Purpose. To explore AA as a possible EIM of IBD and evaluate clinical and investigative findings among patients with IBD-associated AA. Methods. Retrospective chart and literature reviews were performed to find cases of IBD-associated AA at our institution and in the literature. Results. We identified 2 cases of IBD-associated AA in our institution. Both patients had ulcerative colitis and presented with fever, abdominal pain, and weight loss. Radiological workup and aspiration showed sterile splenic abscesses. The AA were unresponsive to antibiotics. One patient improved on corticosteroids and one underwent splenectomy. We retrieved 37 cases of IBD-associated AA from the literature. All patients showed no evidence of infection, failed to resolve with antibiotics, and, if attempted, improved on corticosteroids. Conclusions. Our cases are the first reported in Canada. They support literature which suggests AA as an EIM of IBD and may help increase recognition and reporting of this phenomenon. |
| format | Article |
| id | doaj-art-2f095ed3ff99477ab497a7dd46aad067 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-2f095ed3ff99477ab497a7dd46aad0672025-02-03T06:12:37ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972017-01-01201710.1155/2017/51243545124354Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of LiteratureNatasha Bollegala0Rishad Khan1Michael A. Scaffidi2Ahmed Al-Mazroui3Jenna Tessolini4Adrienne Showler5Errol Colak6Samir C. Grover7Division of Gastroenterology, Women’s College Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Infectious Disease, St. Michael’s Hospital, Toronto, ON, CanadaDepartment of Medical Imaging, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Gastroenterology, St. Michael’s Hospital, Toronto, ON, CanadaBackground. Aseptic abscesses (AA) are sterile lesions that represent an extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Though Canada has the highest prevalence of IBD in the world, reports of IBD-associated AA are absent in Canada. This may represent a different IBD phenotype or underrecognition and underreporting. Purpose. To explore AA as a possible EIM of IBD and evaluate clinical and investigative findings among patients with IBD-associated AA. Methods. Retrospective chart and literature reviews were performed to find cases of IBD-associated AA at our institution and in the literature. Results. We identified 2 cases of IBD-associated AA in our institution. Both patients had ulcerative colitis and presented with fever, abdominal pain, and weight loss. Radiological workup and aspiration showed sterile splenic abscesses. The AA were unresponsive to antibiotics. One patient improved on corticosteroids and one underwent splenectomy. We retrieved 37 cases of IBD-associated AA from the literature. All patients showed no evidence of infection, failed to resolve with antibiotics, and, if attempted, improved on corticosteroids. Conclusions. Our cases are the first reported in Canada. They support literature which suggests AA as an EIM of IBD and may help increase recognition and reporting of this phenomenon.http://dx.doi.org/10.1155/2017/5124354 |
| spellingShingle | Natasha Bollegala Rishad Khan Michael A. Scaffidi Ahmed Al-Mazroui Jenna Tessolini Adrienne Showler Errol Colak Samir C. Grover Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature Canadian Journal of Gastroenterology and Hepatology |
| title | Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature |
| title_full | Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature |
| title_fullStr | Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature |
| title_full_unstemmed | Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature |
| title_short | Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature |
| title_sort | aseptic abscesses and inflammatory bowel disease two cases and review of literature |
| url | http://dx.doi.org/10.1155/2017/5124354 |
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