Structure-guided bispecific antibody engineering confers broad protection against KP.3.1.1 and sarbecoviruses

Structure-guided bispecific antibody engineering confers broad protection against KP.3.1.1 and sarbecoviruses

Summary: The emergence of SARS-CoV-2 variants like KP.2 and KP.3.1.1 challenges COVID-19 countermeasures. Bispecific antibodies (bsAbs) targeting two antigens show promise, but the impact of scFv sequence arrangement on functionality remains unclear. Using neutralizing mAbs 7F3 (Omicron XBB.1-specif...

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Bibliographic Details
Main Authors: Yunping Ma, Qianying Liu, Palizhati Rehati, Zhaoyong Zhang, Yingdan Wang, Zhimin Liu, Jiali Chen, Xuezhou Bai, Aihua Hao, Yanqun Wang, Yumei Wen, Zhenguo Chen, Lu Lu, Jincun Zhao, Fan Wu, Lei Sun, Jinghe Huang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Biochemistry
Immunology
Microbiology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014361
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http://www.sciencedirect.com/science/article/pii/S2589004225014361

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