Gene Polymorphisms in Chronic Periodontitis
We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polym...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2010/324719 |
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| author | Marja L. Laine Bruno G. Loos W. Crielaard |
| author_facet | Marja L. Laine Bruno G. Loos W. Crielaard |
| author_sort | Marja L. Laine |
| collection | DOAJ |
| description | We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polymorphism. Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in the IL1, IL6, IL10, vitamin D receptor, and CD14 genes may be associated with CP in certain populations. However, carriage rates of the rare (𝑅)-allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP. |
| format | Article |
| id | doaj-art-2ee4d8b3d5cb4fe2a665258324179870 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-2ee4d8b3d5cb4fe2a6652583241798702025-02-03T06:42:28ZengWileyInternational Journal of Dentistry1687-87281687-87362010-01-01201010.1155/2010/324719324719Gene Polymorphisms in Chronic PeriodontitisMarja L. Laine0Bruno G. Loos1W. Crielaard2Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The NetherlandsDepartment of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The NetherlandsDepartment of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The NetherlandsWe aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polymorphism. Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in the IL1, IL6, IL10, vitamin D receptor, and CD14 genes may be associated with CP in certain populations. However, carriage rates of the rare (𝑅)-allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.http://dx.doi.org/10.1155/2010/324719 |
| spellingShingle | Marja L. Laine Bruno G. Loos W. Crielaard Gene Polymorphisms in Chronic Periodontitis International Journal of Dentistry |
| title | Gene Polymorphisms in Chronic Periodontitis |
| title_full | Gene Polymorphisms in Chronic Periodontitis |
| title_fullStr | Gene Polymorphisms in Chronic Periodontitis |
| title_full_unstemmed | Gene Polymorphisms in Chronic Periodontitis |
| title_short | Gene Polymorphisms in Chronic Periodontitis |
| title_sort | gene polymorphisms in chronic periodontitis |
| url | http://dx.doi.org/10.1155/2010/324719 |
| work_keys_str_mv | AT marjallaine genepolymorphismsinchronicperiodontitis AT brunogloos genepolymorphismsinchronicperiodontitis AT wcrielaard genepolymorphismsinchronicperiodontitis |