A PAF receptor antagonist inhibits acute airway inflammation and late-phase responses but not chronic airway inflammation and hyperresponsiveness in a primate model of asthma
We have examined the effects of a PAF receptor antagonist, WEB 2170, on several indices of acute and chronic airway inflammation and associated changes in lung function in a primate model of allergic asthma. A single oral administration WEB 2170 provided dose related inhibition of the release of leu...
Saved in:
Main Authors: | R. H. Gundel, C. D. Wegner, H. O. Heuer, L. G. Letts |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
1992-01-01
|
Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/S0962935192000577 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Is platelet activating factor (PAF) an important mediator in bronchial asthma?
by: R. H. Gundel, et al.
Published: (1992-01-01) -
Airway Inflammation and the Pathogenesis of Asthma
by: Paul M O'Byrne
Published: (1994-01-01) -
Hyperresponsiveness in the Human Nasal Airway: New Targets for the Treatment of Allergic Airway Disease
by: P. J. Turner, et al.
Published: (1999-01-01) -
Mechanism of Lower Airway Hyperresponsiveness Induced by Allergic Rhinitis
by: Yiting Liu, et al.
Published: (2022-01-01) -
Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma
by: Girolamo Pelaia, et al.
Published: (2015-01-01)