5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth

5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth

Background: Doxorubicin (DOX), a classical chemotherapeutic agent, faces significant limitations because of its well-documented risk of inducing cardiotoxicity. Effective prevention of DOX-induced cardiotoxicity is urgently needed. Given that alterations in metabolic pathways have been observed in b...

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Bibliographic Details
Main Authors: Xinning Guo, Meng Jiang, Zhengyu Tao, Huijuan Dai, Chen Wu, Yinan Wang, Zi Wang, Xiaoning Wang, Zhixuan Zhang, Kun Qian, Shanshan Zeng, Yihua Bei, Jun Pu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Cardio-oncology
5-oxoproline
Cardiotoxicity
Heart failure
Doxorubicin
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002666
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