Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs
Objective: Overactive bladder (OAB) is a common condition characterized by urinary urgency, frequency, and incontinence. Anticholinergics, beta-3 agonists, and mirabegron are commonly used to manage OAB symptoms. Anticholinergics are effective but may cause side effects such as dry mouth, constipat...
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Rawalpindi Medical University
2023-12-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2275 |
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| author | Nazish Sarfraz Humera Akram Afroza Abbas Sadaf Shaheen Zoobia Ashiq Awan Eesha Yaqoob |
| author_facet | Nazish Sarfraz Humera Akram Afroza Abbas Sadaf Shaheen Zoobia Ashiq Awan Eesha Yaqoob |
| author_sort | Nazish Sarfraz |
| collection | DOAJ |
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Objective: Overactive bladder (OAB) is a common condition characterized by urinary urgency, frequency, and incontinence. Anticholinergics, beta-3 agonists, and mirabegron are commonly used to manage OAB symptoms. Anticholinergics are effective but may cause side effects such as dry mouth, constipation, and drowsiness. Beta-3 agonists, like Mirabegron, are a viable option for individuals seeking to avoid these side effects.
Methods: A study of 45 female patients with OAB symptoms was conducted to evaluate the effectiveness of two cross-over protocols. Group A received mirabegron followed by solifenacin, and group B received mirabegron followed by solifenacin.
Results: The results showed that both treatments were effective in reducing the symptoms of OAB as measured by the IPSS, OABSS, and VAS scores for emergency and distention. The side effects of dry mouth and constipation were relatively mild. However, a p-value of 0.007 shows that there was no significant difference in effectiveness and side effects between the two groups.
Conclusion: Both treatment options can be effective for OAB, but each has specific disadvantages. Consulting with a healthcare provider is important to determine the best treatment option based on an individual's specific needs and medical history.
Keywords: Overactive bladder, Solifenacin, Mirabegron, Anticholinergics.
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| format | Article |
| id | doaj-art-2ec1b89c879b4ccbab2b95b8203f78ac |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-2ec1b89c879b4ccbab2b95b8203f78ac2025-02-06T08:40:37ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702023-12-0127410.37939/jrmc.v27i4.2275Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of DrugsNazish SarfrazHumera AkramAfroza AbbasSadaf ShaheenZoobia Ashiq AwanEesha Yaqoob0Health services academy NIH Objective: Overactive bladder (OAB) is a common condition characterized by urinary urgency, frequency, and incontinence. Anticholinergics, beta-3 agonists, and mirabegron are commonly used to manage OAB symptoms. Anticholinergics are effective but may cause side effects such as dry mouth, constipation, and drowsiness. Beta-3 agonists, like Mirabegron, are a viable option for individuals seeking to avoid these side effects. Methods: A study of 45 female patients with OAB symptoms was conducted to evaluate the effectiveness of two cross-over protocols. Group A received mirabegron followed by solifenacin, and group B received mirabegron followed by solifenacin. Results: The results showed that both treatments were effective in reducing the symptoms of OAB as measured by the IPSS, OABSS, and VAS scores for emergency and distention. The side effects of dry mouth and constipation were relatively mild. However, a p-value of 0.007 shows that there was no significant difference in effectiveness and side effects between the two groups. Conclusion: Both treatment options can be effective for OAB, but each has specific disadvantages. Consulting with a healthcare provider is important to determine the best treatment option based on an individual's specific needs and medical history. Keywords: Overactive bladder, Solifenacin, Mirabegron, Anticholinergics. https://www.journalrmc.com/index.php/JRMC/article/view/2275Overactive bladderSolifenacinMirabegronAnticholinergics |
| spellingShingle | Nazish Sarfraz Humera Akram Afroza Abbas Sadaf Shaheen Zoobia Ashiq Awan Eesha Yaqoob Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs Journal of Rawalpindi Medical College Overactive bladder Solifenacin Mirabegron Anticholinergics |
| title | Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs |
| title_full | Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs |
| title_fullStr | Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs |
| title_full_unstemmed | Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs |
| title_short | Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs |
| title_sort | comparison of outcome and side effects profile of treatment of overactive bladder with different classes of drugs |
| topic | Overactive bladder Solifenacin Mirabegron Anticholinergics |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2275 |
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