Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy
Purpose. This study aimed to measure the concentrations of ferroptosis-related biomarkers, namely, iron (Fe), lipid peroxide (LPO), reactive oxygen species (ROS), glutathione peroxidase-4 (GPX4), and glutathione (GSH) in DR in the attempt to evaluate the diagnostic performance of these biomarkers. M...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/3353740 |
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| _version_ | 1832552834549153792 |
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| author | Lin Mu Dahu Wang Zhiguo Dong Jiajun Wu Xiaoyu Wu Jing Su Yinjian Zhang |
| author_facet | Lin Mu Dahu Wang Zhiguo Dong Jiajun Wu Xiaoyu Wu Jing Su Yinjian Zhang |
| author_sort | Lin Mu |
| collection | DOAJ |
| description | Purpose. This study aimed to measure the concentrations of ferroptosis-related biomarkers, namely, iron (Fe), lipid peroxide (LPO), reactive oxygen species (ROS), glutathione peroxidase-4 (GPX4), and glutathione (GSH) in DR in the attempt to evaluate the diagnostic performance of these biomarkers. Methods. This study included 30 NPDR patients, 30 PDR patients, and 30 healthy subjects matched in age and sex. The concentrations of Fe, LPO, ROS, GPX4, and GSH in serum of the subjects were measured. Results. Compared with the normal group, GPX4 and GSH concentrations were significantly lower, and LPO, Fe, and ROS concentrations were significantly higher in DR patients. Compared with the PDR group, the NPDR group had higher concentrations of LPO, Fe, and ROS and lower concentrations of GPX4 and GSH, but there was no statistical difference in Fe, GPX4, and GSH. ROC curve shows that ferroptosis-related biomarkers have accumulated accuracy in NPDR and PDR. Conclusion. This study shows that ferroptosis-related biomarkers may be involved in the pathological process of DR and can be used as one of the biomarkers of DR. |
| format | Article |
| id | doaj-art-2eb35e26739c4bd59c58df7edc8bfb24 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-2eb35e26739c4bd59c58df7edc8bfb242025-02-03T05:57:38ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/3353740Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic RetinopathyLin Mu0Dahu Wang1Zhiguo Dong2Jiajun Wu3Xiaoyu Wu4Jing Su5Yinjian Zhang6Department of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyDepartment of OphthalmologyPurpose. This study aimed to measure the concentrations of ferroptosis-related biomarkers, namely, iron (Fe), lipid peroxide (LPO), reactive oxygen species (ROS), glutathione peroxidase-4 (GPX4), and glutathione (GSH) in DR in the attempt to evaluate the diagnostic performance of these biomarkers. Methods. This study included 30 NPDR patients, 30 PDR patients, and 30 healthy subjects matched in age and sex. The concentrations of Fe, LPO, ROS, GPX4, and GSH in serum of the subjects were measured. Results. Compared with the normal group, GPX4 and GSH concentrations were significantly lower, and LPO, Fe, and ROS concentrations were significantly higher in DR patients. Compared with the PDR group, the NPDR group had higher concentrations of LPO, Fe, and ROS and lower concentrations of GPX4 and GSH, but there was no statistical difference in Fe, GPX4, and GSH. ROC curve shows that ferroptosis-related biomarkers have accumulated accuracy in NPDR and PDR. Conclusion. This study shows that ferroptosis-related biomarkers may be involved in the pathological process of DR and can be used as one of the biomarkers of DR.http://dx.doi.org/10.1155/2022/3353740 |
| spellingShingle | Lin Mu Dahu Wang Zhiguo Dong Jiajun Wu Xiaoyu Wu Jing Su Yinjian Zhang Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy Journal of Ophthalmology |
| title | Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy |
| title_full | Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy |
| title_fullStr | Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy |
| title_full_unstemmed | Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy |
| title_short | Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy |
| title_sort | abnormal levels of serum ferroptosis related biomarkers in diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2022/3353740 |
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