The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation
Inflammation can cause various chronic diseases like inflammatory bowel diseases. Various food protein-derived bioactive peptides (BAPs) with anti-inflammatory activity have the potential to manage these diseases. The aim of this paper is to overview the mechanisms and the molecular targets of BAPs...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/6817156 |
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| _version_ | 1832546794005856256 |
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| author | Wanying Zhu Liying Ren Li Zhang Qinqin Qiao Muhammad Zahid Farooq Qingbiao Xu |
| author_facet | Wanying Zhu Liying Ren Li Zhang Qinqin Qiao Muhammad Zahid Farooq Qingbiao Xu |
| author_sort | Wanying Zhu |
| collection | DOAJ |
| description | Inflammation can cause various chronic diseases like inflammatory bowel diseases. Various food protein-derived bioactive peptides (BAPs) with anti-inflammatory activity have the potential to manage these diseases. The aim of this paper is to overview the mechanisms and the molecular targets of BAPs to exert anti-inflammatory activity. In this review, the in vitro and in vivo effects of BAPs on intestinal inflammation are highlighted. The mechanism, pathways, and future perspectives of BAPs as the potential sources of therapeutic treatments to alleviate intestinal inflammation are provided, including nuclear factor-κB, mitogen-activated protein kinase, Janus kinase-signal transducer and activator of transcription, and peptide transporter 1 (PepT1), finding that PepT1 and gut microbiota are the promising targets for BAPs to alleviate the intestinal inflammation. This review provides a comprehensive understanding of the role of dietary BAPs in attenuating inflammation and gives a novel direction in nutraceuticals for people or animals with intestinal inflammation. |
| format | Article |
| id | doaj-art-2e9a7cb49f9347e8b975b83cc4d866a1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2e9a7cb49f9347e8b975b83cc4d866a12025-02-03T06:47:04ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/68171566817156The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal InflammationWanying Zhu0Liying Ren1Li Zhang2Qinqin Qiao3Muhammad Zahid Farooq4Qingbiao Xu5Shanxian Central Hospital, Heze 274300, ChinaShanxian Central Hospital, Heze 274300, ChinaShanxian Central Hospital, Heze 274300, ChinaCollege of Information Engineering, Fuyang Normal University, Fuyang 236000, ChinaCollege of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaInflammation can cause various chronic diseases like inflammatory bowel diseases. Various food protein-derived bioactive peptides (BAPs) with anti-inflammatory activity have the potential to manage these diseases. The aim of this paper is to overview the mechanisms and the molecular targets of BAPs to exert anti-inflammatory activity. In this review, the in vitro and in vivo effects of BAPs on intestinal inflammation are highlighted. The mechanism, pathways, and future perspectives of BAPs as the potential sources of therapeutic treatments to alleviate intestinal inflammation are provided, including nuclear factor-κB, mitogen-activated protein kinase, Janus kinase-signal transducer and activator of transcription, and peptide transporter 1 (PepT1), finding that PepT1 and gut microbiota are the promising targets for BAPs to alleviate the intestinal inflammation. This review provides a comprehensive understanding of the role of dietary BAPs in attenuating inflammation and gives a novel direction in nutraceuticals for people or animals with intestinal inflammation.http://dx.doi.org/10.1155/2020/6817156 |
| spellingShingle | Wanying Zhu Liying Ren Li Zhang Qinqin Qiao Muhammad Zahid Farooq Qingbiao Xu The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation Mediators of Inflammation |
| title | The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation |
| title_full | The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation |
| title_fullStr | The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation |
| title_full_unstemmed | The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation |
| title_short | The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation |
| title_sort | potential of food protein derived bioactive peptides against chronic intestinal inflammation |
| url | http://dx.doi.org/10.1155/2020/6817156 |
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