Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways
The use of chemotherapeutic agents during childhood, adolescence, and early adulthood has a detrimental effect on ovarian functions, leading to a decrease in ovarian reserves, thus adversely affecting fertility. Alkylating agents are one of the most frequently used groups of chemotherapeutics in thi...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-12-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Overview-of-the-evaluation-of-the-destructive-effect-of-procarbazine-on-the-ovarian,184349,0,2.html |
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| author | Kezban Kartlasmis Ayse Nur Cakir Gungor Yurdun Kuyucu Samet Kara |
| author_facet | Kezban Kartlasmis Ayse Nur Cakir Gungor Yurdun Kuyucu Samet Kara |
| author_sort | Kezban Kartlasmis |
| collection | DOAJ |
| description | The use of chemotherapeutic agents during childhood, adolescence, and early adulthood has a detrimental effect on ovarian functions, leading to a decrease in ovarian reserves, thus adversely affecting fertility. Alkylating agents are one of the most frequently used groups of chemotherapeutics in this age group. An important and effective chemotherapeutic drug, procarbazine is used to treat brain tumors and Hodgkin lymphoma in children, adolescents, and young adults. This agent is also an indispensable component of combination-type chemotherapy. Procarbazine has a detrimental impact on ovarian reserve by directly targeting the oocyte or indirectly through somatic cell destruction. Evidence gathered thus far indicates that procarbazine’s mode of action in the ovaries may involve apoptosis, inflammation, and oxidative stress. This review seeks to clarify the processes by which procarbazine might induce apoptosis, inflammation, and oxidative stress, hence affecting ovarian reserve and functioning. |
| format | Article |
| id | doaj-art-2e7f7cfeb2ff464ca50a3fa8eba26900 |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-2e7f7cfeb2ff464ca50a3fa8eba269002025-01-27T10:45:12ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-12-012061793179610.5114/aoms/184349184349Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathwaysKezban Kartlasmis0Ayse Nur Cakir Gungor1Yurdun Kuyucu2Samet Kara3Institute of Health Sciences, Cukurova University, Adana,TurkeyAdanus Women’s Health Research Group, Cukurova University, Adana,TurkeyDepartment of Histology and Embryology, Faculty of Medicine, Cukurova University, Adana, TurkeyDepartment of Histology and Embryology, Faculty of Medicine, Cukurova University, Adana, TurkeyThe use of chemotherapeutic agents during childhood, adolescence, and early adulthood has a detrimental effect on ovarian functions, leading to a decrease in ovarian reserves, thus adversely affecting fertility. Alkylating agents are one of the most frequently used groups of chemotherapeutics in this age group. An important and effective chemotherapeutic drug, procarbazine is used to treat brain tumors and Hodgkin lymphoma in children, adolescents, and young adults. This agent is also an indispensable component of combination-type chemotherapy. Procarbazine has a detrimental impact on ovarian reserve by directly targeting the oocyte or indirectly through somatic cell destruction. Evidence gathered thus far indicates that procarbazine’s mode of action in the ovaries may involve apoptosis, inflammation, and oxidative stress. This review seeks to clarify the processes by which procarbazine might induce apoptosis, inflammation, and oxidative stress, hence affecting ovarian reserve and functioning.https://www.archivesofmedicalscience.com/Overview-of-the-evaluation-of-the-destructive-effect-of-procarbazine-on-the-ovarian,184349,0,2.htmlapoptosisinflammationoxidative stressovarian reserveprocarbazine |
| spellingShingle | Kezban Kartlasmis Ayse Nur Cakir Gungor Yurdun Kuyucu Samet Kara Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways Archives of Medical Science apoptosis inflammation oxidative stress ovarian reserve procarbazine |
| title | Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways |
| title_full | Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways |
| title_fullStr | Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways |
| title_full_unstemmed | Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways |
| title_short | Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways |
| title_sort | overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic inflammatory and oxidative pathways |
| topic | apoptosis inflammation oxidative stress ovarian reserve procarbazine |
| url | https://www.archivesofmedicalscience.com/Overview-of-the-evaluation-of-the-destructive-effect-of-procarbazine-on-the-ovarian,184349,0,2.html |
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