An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome
Hemophagocytic syndrome (HS) or hemophagocytic lymphohistiocytosis (HLH) is an immune mediated phenomenon that can occur in the setting of an autoimmune disease, chronic immunosuppression, malignancy, or infection. It has been more commonly described in the pediatric population and less commonly in...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2016/8957690 |
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| _version_ | 1832562351501475840 |
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| author | Saika Sharmeen Nazia Hussain |
| author_facet | Saika Sharmeen Nazia Hussain |
| author_sort | Saika Sharmeen |
| collection | DOAJ |
| description | Hemophagocytic syndrome (HS) or hemophagocytic lymphohistiocytosis (HLH) is an immune mediated phenomenon that can occur in the setting of an autoimmune disease, chronic immunosuppression, malignancy, or infection. It has been more commonly described in the pediatric population and less commonly in adults. We describe a case of a 52-year-old male who presented with a rash. He simultaneously met the Systemic Lupus International Collaborating Clinics (SLICC) criteria for the diagnosis of systemic lupus erythematosus (SLE) and the diagnostic criteria of HS as described in the hemophagocytic lymphohistiocytosis (HLH) 2004 trial. The bone marrow on autopsy showed the presence of abundant hemosiderophages with focal hemophagocytosis. SLE-associated HS might be underdiagnosed due to the overlap in clinical findings. This case represents the importance of prompt diagnosis and treatment of such a potentially fatal clinical syndrome. |
| format | Article |
| id | doaj-art-2e7c252243e54aafae9f47ddd6875165 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-2e7c252243e54aafae9f47ddd68751652025-02-03T01:22:50ZengWileyCase Reports in Rheumatology2090-68892090-68972016-01-01201610.1155/2016/89576908957690An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic SyndromeSaika Sharmeen0Nazia Hussain1Department of Medicine, St. Luke’s-Roosevelt Hospital Center, New York, NY 10025, USADepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10025, USAHemophagocytic syndrome (HS) or hemophagocytic lymphohistiocytosis (HLH) is an immune mediated phenomenon that can occur in the setting of an autoimmune disease, chronic immunosuppression, malignancy, or infection. It has been more commonly described in the pediatric population and less commonly in adults. We describe a case of a 52-year-old male who presented with a rash. He simultaneously met the Systemic Lupus International Collaborating Clinics (SLICC) criteria for the diagnosis of systemic lupus erythematosus (SLE) and the diagnostic criteria of HS as described in the hemophagocytic lymphohistiocytosis (HLH) 2004 trial. The bone marrow on autopsy showed the presence of abundant hemosiderophages with focal hemophagocytosis. SLE-associated HS might be underdiagnosed due to the overlap in clinical findings. This case represents the importance of prompt diagnosis and treatment of such a potentially fatal clinical syndrome.http://dx.doi.org/10.1155/2016/8957690 |
| spellingShingle | Saika Sharmeen Nazia Hussain An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome Case Reports in Rheumatology |
| title | An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome |
| title_full | An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome |
| title_fullStr | An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome |
| title_full_unstemmed | An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome |
| title_short | An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome |
| title_sort | unusual case of systemic lupus erythematosus and hemophagocytic syndrome |
| url | http://dx.doi.org/10.1155/2016/8957690 |
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