Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances
Abstract Objective To investigate the effects of modified twin-block appliances (MTBA) on obstructive sleep apnea (OSA) and mandibular retrognathia and the changes in the upper airway, hyoid bone position, and hypoxia-related inflammatory marker levels in children with OSA. Methods This study includ...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12903-025-05528-y |
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| author | Jun Duan Wanyuan Xia Xuelei Li Feng Zhang Fan Wang Mengwei Chen Qian Chen Bing Wang Bing Li |
| author_facet | Jun Duan Wanyuan Xia Xuelei Li Feng Zhang Fan Wang Mengwei Chen Qian Chen Bing Wang Bing Li |
| author_sort | Jun Duan |
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| description | Abstract Objective To investigate the effects of modified twin-block appliances (MTBA) on obstructive sleep apnea (OSA) and mandibular retrognathia and the changes in the upper airway, hyoid bone position, and hypoxia-related inflammatory marker levels in children with OSA. Methods This study included children with OSA and mandibular retrognathia and those with class I without mandibular retrognathia (n = 35 each). The experimental group comprised children with OSA and mandibular retrognathia managed using MTBA. Postoperative and preoperative polysomnography, lateral cephalometric radiographs, and peripheral blood samples were collected. The control group comprised children with class I without mandibular retrognathia. Results Following MTBA management, the experimental group exhibited decreased apnea–hypopnea index and increased lowest arterial oxygen saturation level (P < 0.05). Sella- and subspinale-nasion-supramental angles significantly increased and decreased, respectively (P < 0.05). Posterior soft palatal–posterior pharyngeal wall distance, apical palatal–middle pharyngeal wall distance, posterior airway space, epiglottis valley–hypopharyngeal wall distance, hyoid–prevertebral plane distance, and distance from the superior anterior point of the hyoid bone to the inferior anterior point of the third cervical spine significantly increased, whereas distance from the superior anterior point of the hyoid bone to the mandibular plane decreased (P < 0.05). Conclusions Children with OSA (n = 35) were managed using MTBA, which relieved the mandibular retrognathia deformity, widened the upper airway space, moved the hyoid bone forward and upward, and improved the sleep monitoring indicators. Thus, MTBA can achieve satisfactory therapeutic effect in children with OSA and mandibular retrognathia with mandibular advancement. |
| format | Article |
| id | doaj-art-2e744506f41742a88f19c94dfde0174f |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-2e744506f41742a88f19c94dfde0174f2025-02-02T12:45:21ZengBMCBMC Oral Health1472-68312025-01-0125111010.1186/s12903-025-05528-yAirway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliancesJun Duan0Wanyuan Xia1Xuelei Li2Feng Zhang3Fan Wang4Mengwei Chen5Qian Chen6Bing Wang7Bing Li8Department of Stomatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children’s Hospital of Chongqing Medical UniversityDepartment of Public Health and Management, Chongqing Three Gorges Medical CollegeDepartment of Otolaryngology, Children’s Hospital of Chongqing Medical UniversityDepartment of Otolaryngology, Children’s Hospital of Chongqing Medical UniversityDepartment of Otolaryngology, Children’s Hospital of Chongqing Medical UniversityDepartment of Stomatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children’s Hospital of Chongqing Medical UniversityDepartment of Stomatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children’s Hospital of Chongqing Medical UniversityDepartment of Otolaryngology, Children’s Hospital of Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical UniversityAbstract Objective To investigate the effects of modified twin-block appliances (MTBA) on obstructive sleep apnea (OSA) and mandibular retrognathia and the changes in the upper airway, hyoid bone position, and hypoxia-related inflammatory marker levels in children with OSA. Methods This study included children with OSA and mandibular retrognathia and those with class I without mandibular retrognathia (n = 35 each). The experimental group comprised children with OSA and mandibular retrognathia managed using MTBA. Postoperative and preoperative polysomnography, lateral cephalometric radiographs, and peripheral blood samples were collected. The control group comprised children with class I without mandibular retrognathia. Results Following MTBA management, the experimental group exhibited decreased apnea–hypopnea index and increased lowest arterial oxygen saturation level (P < 0.05). Sella- and subspinale-nasion-supramental angles significantly increased and decreased, respectively (P < 0.05). Posterior soft palatal–posterior pharyngeal wall distance, apical palatal–middle pharyngeal wall distance, posterior airway space, epiglottis valley–hypopharyngeal wall distance, hyoid–prevertebral plane distance, and distance from the superior anterior point of the hyoid bone to the inferior anterior point of the third cervical spine significantly increased, whereas distance from the superior anterior point of the hyoid bone to the mandibular plane decreased (P < 0.05). Conclusions Children with OSA (n = 35) were managed using MTBA, which relieved the mandibular retrognathia deformity, widened the upper airway space, moved the hyoid bone forward and upward, and improved the sleep monitoring indicators. Thus, MTBA can achieve satisfactory therapeutic effect in children with OSA and mandibular retrognathia with mandibular advancement.https://doi.org/10.1186/s12903-025-05528-yObstructive sleep apneaMandibular retrognathiaModified twin-block appliance2-D radiographic cephalometricAirway dimensions |
| spellingShingle | Jun Duan Wanyuan Xia Xuelei Li Feng Zhang Fan Wang Mengwei Chen Qian Chen Bing Wang Bing Li Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances BMC Oral Health Obstructive sleep apnea Mandibular retrognathia Modified twin-block appliance 2-D radiographic cephalometric Airway dimensions |
| title | Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances |
| title_full | Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances |
| title_fullStr | Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances |
| title_full_unstemmed | Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances |
| title_short | Airway morphology, hyoid position, and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin-block appliances |
| title_sort | airway morphology hyoid position and serum inflammatory markers of obstructive sleep apnea in children treated with modified twin block appliances |
| topic | Obstructive sleep apnea Mandibular retrognathia Modified twin-block appliance 2-D radiographic cephalometric Airway dimensions |
| url | https://doi.org/10.1186/s12903-025-05528-y |
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