Elucidation of the mechanism Underlying the promotion of ferroptosis and enhanced antitumor immunity by citrus polymethoxyflavones in CRC cells

Elucidation of the mechanism Underlying the promotion of ferroptosis and enhanced antitumor immunity by citrus polymethoxyflavones in CRC cells

BackgroundColon cancer is a prevalent condition with a high mortality rate on a global scale. Research has indicated that Citrus polymethoxyflavones (PMFs), a class of flavonoids found in Citrus, possess the potential to demonstrate anti-tumor efficacy. Ferroptosis a form of cell death that is depen...

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Bibliographic Details
Main Authors: Yingying Duan, Yu Wu, Jiaqi Tian, Yuqin Yin, Zhongwen Yuan, Wenting Zhu, Suyue Zhou, Chen Li, Senling Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
colon cancer
citrus polymethoxyflavones
ferroptosis
PD-L1
antitumor immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1571178/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1571178/full

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