Influence of Feeding on IL-2 Gene Expression and Peak Blood Cyclosporine Concentration in Healthy Dogs Administered Oral Cyclosporine

Influence of Feeding on IL-2 Gene Expression and Peak Blood Cyclosporine Concentration in Healthy Dogs Administered Oral Cyclosporine

The administration of modified cyclosporine with food has been reported to decrease oral bioavailability. The objective of this study was to compare the pharmacodynamic effects of oral modified cyclosporine in healthy dogs when administered with and without food. In this randomized, crossover study,...

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Bibliographic Details
Main Authors: Marianne Pan, Todd Archer, Andrew Mackin, Robert Wills, Lakshmi Narayanan, Jana Raessler, Stacie Summers
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pets
Subjects:
cyclosporine
immunosuppression
pharmacodynamic
interleukin-2 (IL-2)
quantitative reverse transcription PCR (qRT-PCR)
Online Access:https://www.mdpi.com/2813-9372/1/3/24
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