Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience
Background. There is clinical importance to investigate the disease progression through potential biomarkers of SARS-CoV-2 infection. In the present study, we aim to evaluate the significance of inflammatory markers in different categories of COVID-19 in admitted patients. Methods. In a single-cente...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2021/6643333 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550473523003392 |
|---|---|
| author | Maria Khan Noman Shah Hina Mushtaq Valeed Jehanzeb |
| author_facet | Maria Khan Noman Shah Hina Mushtaq Valeed Jehanzeb |
| author_sort | Maria Khan |
| collection | DOAJ |
| description | Background. There is clinical importance to investigate the disease progression through potential biomarkers of SARS-CoV-2 infection. In the present study, we aim to evaluate the significance of inflammatory markers in different categories of COVID-19 in admitted patients. Methods. In a single-center, observational study of 50 in-hospital patients who were diagnosed with COVID-19 and admitted to the intensive care unit of a tertiary care hospital in Peshawar, infection biomarkers, including hs-CRP, serum ferritin, serum creatinine, ALT, ALP, cardiac troponin-I, and IL-6 were analyzed. Results. The median age was 61.3 years. 70% (35) were male while 30% (15) were female. We noted significantly increased hs-CRP (9.32 mg/dL ± 10.03) and ferritin levels (982.3 ng/ml ± 601.9). A noteworthy increase was observed in neutrophil count (11.05 × 109/L) and a decrease was observed in lymphocyte count (0.27 × 109/L) (P<0.05), and the platelet count was borderline decreased (244.1 × 109/L). IL-6 levels were markedly increased in all admitted patients (100.2 pg/ml ± 122.2 pg/ml). Conclusion. The serum levels of CRP, troponin-I, ALP, ALT, serum creatinine, and ferritin are markedly increased in COVID-19 patients. Increased CRP and ferritin levels were also associated with secondary bacterial infection and poor clinical outcomes. |
| format | Article |
| id | doaj-art-2e051cf656bd41e6905fc78bca685576 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-2e051cf656bd41e6905fc78bca6855762025-02-03T06:06:34ZengWileyInternational Journal of Microbiology1687-918X1687-91982021-01-01202110.1155/2021/66433336643333Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center ExperienceMaria Khan0Noman Shah1Hina Mushtaq2Valeed Jehanzeb3Pathology Department, Rehman Medical Institute, Peshawar, PakistanPathology Department, Rehman Medical Institute, Peshawar, PakistanPathology Department, Rehman Medical Institute, Peshawar, PakistanPathology Department, Rehman Medical Institute, Peshawar, PakistanBackground. There is clinical importance to investigate the disease progression through potential biomarkers of SARS-CoV-2 infection. In the present study, we aim to evaluate the significance of inflammatory markers in different categories of COVID-19 in admitted patients. Methods. In a single-center, observational study of 50 in-hospital patients who were diagnosed with COVID-19 and admitted to the intensive care unit of a tertiary care hospital in Peshawar, infection biomarkers, including hs-CRP, serum ferritin, serum creatinine, ALT, ALP, cardiac troponin-I, and IL-6 were analyzed. Results. The median age was 61.3 years. 70% (35) were male while 30% (15) were female. We noted significantly increased hs-CRP (9.32 mg/dL ± 10.03) and ferritin levels (982.3 ng/ml ± 601.9). A noteworthy increase was observed in neutrophil count (11.05 × 109/L) and a decrease was observed in lymphocyte count (0.27 × 109/L) (P<0.05), and the platelet count was borderline decreased (244.1 × 109/L). IL-6 levels were markedly increased in all admitted patients (100.2 pg/ml ± 122.2 pg/ml). Conclusion. The serum levels of CRP, troponin-I, ALP, ALT, serum creatinine, and ferritin are markedly increased in COVID-19 patients. Increased CRP and ferritin levels were also associated with secondary bacterial infection and poor clinical outcomes.http://dx.doi.org/10.1155/2021/6643333 |
| spellingShingle | Maria Khan Noman Shah Hina Mushtaq Valeed Jehanzeb Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience International Journal of Microbiology |
| title | Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience |
| title_full | Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience |
| title_fullStr | Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience |
| title_full_unstemmed | Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience |
| title_short | Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience |
| title_sort | profiling laboratory biomarkers associated with covid 19 disease progression a single center experience |
| url | http://dx.doi.org/10.1155/2021/6643333 |
| work_keys_str_mv | AT mariakhan profilinglaboratorybiomarkersassociatedwithcovid19diseaseprogressionasinglecenterexperience AT nomanshah profilinglaboratorybiomarkersassociatedwithcovid19diseaseprogressionasinglecenterexperience AT hinamushtaq profilinglaboratorybiomarkersassociatedwithcovid19diseaseprogressionasinglecenterexperience AT valeedjehanzeb profilinglaboratorybiomarkersassociatedwithcovid19diseaseprogressionasinglecenterexperience |