Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario
The use of spinal fusion procedures has rapidly augmented over the last decades and although autogenous bone graft is the “gold standard” for these procedures, alternatives to its use have been investigated over many years. A number of emerging strategies as well as tissue engineering with mesenchym...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/3537094 |
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| author | F. Salamanna M. Sartori G. Barbanti Brodano C. Griffoni L. Martini S. Boriani M. Fini |
| author_facet | F. Salamanna M. Sartori G. Barbanti Brodano C. Griffoni L. Martini S. Boriani M. Fini |
| author_sort | F. Salamanna |
| collection | DOAJ |
| description | The use of spinal fusion procedures has rapidly augmented over the last decades and although autogenous bone graft is the “gold standard” for these procedures, alternatives to its use have been investigated over many years. A number of emerging strategies as well as tissue engineering with mesenchymal stem cells (MSCs) have been planned to enhance spinal fusion rate. This descriptive systematic literature review summarizes the in vivo studies, dealing with the use of MSCs in spinal arthrodesis surgery and the state of the art in clinical applications. The review has yielded promising evidence supporting the use of MSCs as a cell-based therapy in spinal fusion procedures, thus representing a suitable biological approach able to reduce the high cost of osteoinductive factors as well as the high dose needed to induce bone formation. Nevertheless, despite the fact that MSCs therapy is an interesting and important opportunity of research, in this review it was detected that there are still doubts about the optimal cell concentration and delivery method as well as the ideal implantation techniques and the type of scaffolds for cell delivery. Thus, further inquiry is necessary to carefully evaluate the clinical safety and efficacy of MSCs use in spine fusion. |
| format | Article |
| id | doaj-art-2e006b5db14d4886a68ac4efc134474b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2e006b5db14d4886a68ac4efc134474b2025-02-03T01:22:51ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/35370943537094Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical ScenarioF. Salamanna0M. Sartori1G. Barbanti Brodano2C. Griffoni3L. Martini4S. Boriani5M. Fini6Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, ItalyLaboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Rizzoli Research Innovation Technology Department, Rizzoli Orthopedic Institute, Bologna, ItalyDepartment of Oncological and Degenerative Spine Surgery, Rizzoli Orthopedic Institute, Bologna, ItalyDepartment of Oncological and Degenerative Spine Surgery, Rizzoli Orthopedic Institute, Bologna, ItalyLaboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, ItalyDepartment of Oncological and Degenerative Spine Surgery, Rizzoli Orthopedic Institute, Bologna, ItalyLaboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, ItalyThe use of spinal fusion procedures has rapidly augmented over the last decades and although autogenous bone graft is the “gold standard” for these procedures, alternatives to its use have been investigated over many years. A number of emerging strategies as well as tissue engineering with mesenchymal stem cells (MSCs) have been planned to enhance spinal fusion rate. This descriptive systematic literature review summarizes the in vivo studies, dealing with the use of MSCs in spinal arthrodesis surgery and the state of the art in clinical applications. The review has yielded promising evidence supporting the use of MSCs as a cell-based therapy in spinal fusion procedures, thus representing a suitable biological approach able to reduce the high cost of osteoinductive factors as well as the high dose needed to induce bone formation. Nevertheless, despite the fact that MSCs therapy is an interesting and important opportunity of research, in this review it was detected that there are still doubts about the optimal cell concentration and delivery method as well as the ideal implantation techniques and the type of scaffolds for cell delivery. Thus, further inquiry is necessary to carefully evaluate the clinical safety and efficacy of MSCs use in spine fusion.http://dx.doi.org/10.1155/2017/3537094 |
| spellingShingle | F. Salamanna M. Sartori G. Barbanti Brodano C. Griffoni L. Martini S. Boriani M. Fini Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario Stem Cells International |
| title | Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario |
| title_full | Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario |
| title_fullStr | Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario |
| title_full_unstemmed | Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario |
| title_short | Mesenchymal Stem Cells for the Treatment of Spinal Arthrodesis: From Preclinical Research to Clinical Scenario |
| title_sort | mesenchymal stem cells for the treatment of spinal arthrodesis from preclinical research to clinical scenario |
| url | http://dx.doi.org/10.1155/2017/3537094 |
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