Urine miRNA signature as potential non-invasive diagnostic biomarker for Hirschsprung’s disease

Urine miRNA signature as potential non-invasive diagnostic biomarker for Hirschsprung’s disease

Hirschsprung’s disease (HSCR) is characterized by congenital absence of ganglion cells in the gastrointestinal tract, which leads to impaired defecation, constipation and intestinal obstruction. The current diagnosis of HSCR is based on Rectal Suction Biopsies (RSBs), which could be complex in newbo...

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Bibliographic Details
Main Authors: Abhijit Sreepada, Rasul Khasanov, Enas Zoheer Elkrewi, Carolina de la Torre, Judith Felcht, Ahmad A. Al Abdulqader, Richard Martel, Nicolás Andrés Hoyos-Celis, Michael Boettcher, Lucas M. Wessel, Karl-Herbert Schäfer, María Ángeles Tapia-Laliena
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Hirschsprung’s disease (HSCR)
enteric nervous system (ENS)
microRNA (miRNA)
non-invasive diagnostic
urine extracellular vesicles
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1504424/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2024.1504424/full

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