Fludarabine attenuates inflammation and dysregulated autophagy in alveolar macrophages via inhibition of STAT1/IRF1 pathway

Fludarabine attenuates inflammation and dysregulated autophagy in alveolar macrophages via inhibition of STAT1/IRF1 pathway

Abstract Background Acute lung injury (ALI), including its most severe form, acute respiratory distress syndrome (ARDS), is a common cause of acute hypoxemic respiratory failure. Although its clinical characteristics have been well characterized, the relevant mechanism remains unclear. An imbalance...

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Main Authors: Jooyeon Lee, Jeong-Ran Park, Hanbyeol Lee, Seok-Ho Hong, Woo Jin Kim, Oliver Eickelberg, Sung-Min Park, Semin Ryu, Sung Joon Cho, Seung-Jin Kim, Se-Ran Yang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Laboratory Animal Research
Subjects:
Acute lung injury
STAT1
IRF1
Fludarabine
Autophagy
Inflammation
Online Access:https://doi.org/10.1186/s42826-025-00245-7
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https://doi.org/10.1186/s42826-025-00245-7

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