The Role of SGLT2-Inhibitors Across All Stages of Heart Failure and Mechanisms of Early Clinical Benefit: From Prevention to Advanced Heart Failure

The Role of SGLT2-Inhibitors Across All Stages of Heart Failure and Mechanisms of Early Clinical Benefit: From Prevention to Advanced Heart Failure

Sodium-glucose cotransporter-2 inhibitors (SGLT2i), initially developed as antihyperglycemic agents, have revolutionized heart failure (HF) management, offering substantial benefits across all stages and phenotypes of the disease. Regardless of left ventricular ejection fraction (LVEF), these agents...

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Bibliographic Details
Main Authors: Simone Pasquale Crispino, Andrea Segreti, Vincenzo Nafisio, Daniele Valente, Filippo Crisci, Aurora Ferro, Ilaria Cavallari, Annunziata Nusca, Gian Paolo Ussia, Francesco Grigioni
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomedicines
Subjects:
acute heart failure (AHF)
chronic heart failure (CHF)
four pillars
foundational therapy
GDMT
heart failure (HF)
Online Access:https://www.mdpi.com/2227-9059/13/3/608
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