A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling

A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling

Summary: The Vps10p-domain receptors SorCS1-3 have been repeatedly associated with the development of neurological and psychiatric disorders. They have emerged as key regulators of synaptic activity and neurotrophic signaling, but the underlying molecular mechanism remains poorly understood. Here we...

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Bibliographic Details
Main Authors: Anders Dalby, Mathias Kaas, Lars Meinertz Byg, Signe Bundgaard Christiansen, Christian M. Longworth, Simon Bøggild Hansen, Per Qvist, Jens R. Nyengaard, Peder Madsen, Simon Mølgaard, Simon Glerup
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Molecular biology
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225009563
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