Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein

Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein

Abstract Vacuolar protein sorting-associated protein 35 (VPS35), a pivotal constituent of the retromer complex, mediates the retrograde trafficking of endosomal cargoes in the cytoplasm. Intriguingly, VPS35 displays a dual localization pattern, residing both in the cytoplasm and the nucleus, but its...

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Bibliographic Details
Main Authors: Luping Zhang, Yonghong Nie, Tuo Tang, Yanji Lu, Wenlong Li, Xian Hong, Qiang Li, Aixue Zheng, Yongpei Li, Jianwen Zhou, Li Fan, Tao Wang, Zhihui Deng
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
VPS35
Non-homologous end joining
DNA repair
Ku
Online Access:https://doi.org/10.1186/s10020-025-01288-1
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https://doi.org/10.1186/s10020-025-01288-1

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