Genetic polymorphisms in human CX3CR1-mediated macrophage dysregulation are associated with the worsening of hearing loss and cochlear degeneration after noise trauma: a study in a humanized mouse model

Genetic polymorphisms in human CX3CR1-mediated macrophage dysregulation are associated with the worsening of hearing loss and cochlear degeneration after noise trauma: a study in a humanized mouse model

Abstract Sensorineural hearing loss (SNHL) is characterized by cochlear inflammation, macrophage activation, and degeneration of hair cells, synapses, and neurons. Macrophage-mediated inflammation in the damaged cochlea is regulated via CX3CR1-CX3CL1 signaling, where the fractalkine ligand CX3CL1 se...

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Main Authors: Dinesh Y. Gawande, Sree Varshini Murali, Shriti S. Thakur, Savlatjon Rahmatulloev, Emma J. Nicolaisen, Lyudmila Batalkina, Astrid E. Cardona, Tejbeer Kaur
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Neuroinflammation
Subjects:
Macrophage
Fractalkine
CX3CR1
Polymorphism
Hearing loss
Noise trauma
Online Access:https://doi.org/10.1186/s12974-025-03524-1
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https://doi.org/10.1186/s12974-025-03524-1

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