Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer

Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer

Abstract Background Many factors, including environmental and genetic variables, contribute to Colorectal Cancer (CRC) risk. The genetic components of risk can be divided into monogenic and polygenic factors. Just as monogenic factors can increase risk for more than one condition, polygenic factors...

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Main Authors: Elisabeth A. Rosenthal, Wei-Qi Wei, Yuan Luo, Bahram Namjou-Khales, Daniel J. Schaid, Edward D. Esplin, Michael Lape, Leah Kottyan, Jennifer Allen Pacheco, Chunhua Weng, Adam Samuel Gordon, Iftikhar J. Kullo, David R. Crosslin, William M. Grady, Li Hsu, Ulrike Peters, Gail P. Jarvik
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Human Genomics
Subjects:
PheWAS
Cross-trait genetic correlation
Polygenic risk
Colorectal cancer
UK Biobank
eMERGE
Online Access:https://doi.org/10.1186/s40246-025-00791-0
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https://doi.org/10.1186/s40246-025-00791-0

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