Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura
Nocardia transvalensis complex includes a wide range of microorganisms with specific antimicrobial resistance patterns. N. transvalensis is an unusual Nocardia species. However, it must be differentiated due to its natural resistance to aminoglycosides while other Nocardia species are susceptible. T...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/3818969 |
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| author | Jorge García-Méndez Erika M. Carrillo-Casas Andrea Rangel-Cordero Margarita Leyva-Leyva Juan Xicohtencatl-Cortes Roberto Arenas Rigoberto Hernández-Castro |
| author_facet | Jorge García-Méndez Erika M. Carrillo-Casas Andrea Rangel-Cordero Margarita Leyva-Leyva Juan Xicohtencatl-Cortes Roberto Arenas Rigoberto Hernández-Castro |
| author_sort | Jorge García-Méndez |
| collection | DOAJ |
| description | Nocardia transvalensis complex includes a wide range of microorganisms with specific antimicrobial resistance patterns. N. transvalensis is an unusual Nocardia species. However, it must be differentiated due to its natural resistance to aminoglycosides while other Nocardia species are susceptible. The present report describes a Nocardia species involved in an uncommon clinical case of a patient with idiopathic thrombocytopenic purpura and pulmonary nocardiosis. Microbiological and molecular techniques based on the sequencing of the 16S rRNA gene allowed diagnosis of Nocardia transvalensis sensu stricto. The successful treatment was based on trimethoprim-sulfamethoxazole and other drugs. We conclude that molecular identification of Nocardia species is a valuable technique to guide good treatment and prognosis and recommend its use for daily bases diagnosis. |
| format | Article |
| id | doaj-art-2d697318583d4a8fbc28ebb5fc37b8d9 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-2d697318583d4a8fbc28ebb5fc37b8d92025-02-03T06:01:32ZengWileyCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/38189693818969Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic PurpuraJorge García-Méndez0Erika M. Carrillo-Casas1Andrea Rangel-Cordero2Margarita Leyva-Leyva3Juan Xicohtencatl-Cortes4Roberto Arenas5Rigoberto Hernández-Castro6Departamento de Posgrado y Educación Médica Continua, Instituto Nacional de Cancerología, MexicoDepartamento de Biología Molecular e Histocompatibilidad, Dirección de Investigación, Hospital General “Dr. Manuel Gea González”, 14080 Tlalpan, MEX, MexicoLaboratorio de Microbiología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, 14080 Tlalpan, MEX, MexicoDepartamento de Biología Molecular e Histocompatibilidad, Dirección de Investigación, Hospital General “Dr. Manuel Gea González”, 14080 Tlalpan, MEX, MexicoDepartamento de Infectología, Hospital Infantil de México “Federico Gómez”, Dr. Márquez 162, Cuauhtémoc, 06720 Ciudad de México, DF, MexicoServicio de Micología, Hospital General “Dr. Manuel Gea González”, 14080 Tlalpan, MEX, MexicoDepartamento de Ecología de Agentes Patógenos, Hospital General “Dr. Manuel Gea González”, 14080 Tlalpan, MEX, MexicoNocardia transvalensis complex includes a wide range of microorganisms with specific antimicrobial resistance patterns. N. transvalensis is an unusual Nocardia species. However, it must be differentiated due to its natural resistance to aminoglycosides while other Nocardia species are susceptible. The present report describes a Nocardia species involved in an uncommon clinical case of a patient with idiopathic thrombocytopenic purpura and pulmonary nocardiosis. Microbiological and molecular techniques based on the sequencing of the 16S rRNA gene allowed diagnosis of Nocardia transvalensis sensu stricto. The successful treatment was based on trimethoprim-sulfamethoxazole and other drugs. We conclude that molecular identification of Nocardia species is a valuable technique to guide good treatment and prognosis and recommend its use for daily bases diagnosis.http://dx.doi.org/10.1155/2016/3818969 |
| spellingShingle | Jorge García-Méndez Erika M. Carrillo-Casas Andrea Rangel-Cordero Margarita Leyva-Leyva Juan Xicohtencatl-Cortes Roberto Arenas Rigoberto Hernández-Castro Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura Case Reports in Infectious Diseases |
| title | Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura |
| title_full | Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura |
| title_fullStr | Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura |
| title_full_unstemmed | Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura |
| title_short | Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura |
| title_sort | nocardia transvalensis disseminated infection in an immunocompromised patient with idiopathic thrombocytopenic purpura |
| url | http://dx.doi.org/10.1155/2016/3818969 |
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