Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy
[Objective] To explore the predictive value of HALP score for prognosis in patients with multiple myeloma (MM). [Methods] A retrospective analysis was conducted on laboratory indicators and related clinical data of newly diagnosed multiple myeloma (NDMM) patients, treated at the Affiliated Hospital...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-01-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.010&lang=en |
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| author | CHEN Min AN Liying LIN Xiaojing ZHAO Pan ZOU Xingli WEI Jin NI Xun |
| author_facet | CHEN Min AN Liying LIN Xiaojing ZHAO Pan ZOU Xingli WEI Jin NI Xun |
| author_sort | CHEN Min |
| collection | DOAJ |
| description | [Objective] To explore the predictive value of HALP score for prognosis in patients with multiple myeloma (MM). [Methods] A retrospective analysis was conducted on laboratory indicators and related clinical data of newly diagnosed multiple myeloma (NDMM) patients, treated at the Affiliated Hospital of North Sichuan Medical College from January 2016 to October 2023, prior to their first treatment. The HALP score was calculated, and the optimal cutoff value for HALP was determined using X-tile software. Survival analysis was performed using Kaplan-Meier curves for high HALP and low HALP groups. Univariate and multivariate analyses were conducted using the Cox regression model, and a forest plot was generated using Graphpad Prism to illustrate factors that may impact patient prognosis. The predictive ability of HALP score combined with β2-microglobulin and ECOG score for prognosis in MM patients was evaluated using receiver operating characteristic curve (ROC) analysis. [Results] A total of 203 MM patients were included, with the optimal cutoff value for HALP score being 29.15 (P<0.05). Among them, 101 patients were in the low HALP score group, and 102 patients were in the high HALP score group. The results of univariate and multivariate analysis using the Cox regression model showed that a HALP score <29.15 was an independent risk factor for progression-free survival (PFS) and overall survival (OS) (P<0.05). ROC curve analysis indicated that the combination of HALP score with β2-microglobulin and ECOG score had a higher predictive value for prognosis in MM patients compared to using HALP score alone. [Conclusion] The HALP score is closely related to the prognosis of patients with NDMM. A low HALP score indicates a poorer prognosis, while the combination of HALP score with β2-microglobulin and ECOG score provides a higher predictive value when assessed together. |
| format | Article |
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| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-2d3f874ebab14288bd77ccb3c0fccf052025-01-27T01:46:11ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-01-01381616710.13303/j.cjbt.issn.1004-549x.2025.01.0101004-549X(2025)1-0061-08Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapyCHEN Min0AN Liying1LIN Xiaojing2ZHAO Pan3ZOU Xingli4WEI Jin5NI Xun6Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, ChinaDepartment of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, ChinaDepartment of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, ChinaDepartment of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, ChinaDepartment of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, ChinaDepartment of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, ChinaDepartment of Hematology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China[Objective] To explore the predictive value of HALP score for prognosis in patients with multiple myeloma (MM). [Methods] A retrospective analysis was conducted on laboratory indicators and related clinical data of newly diagnosed multiple myeloma (NDMM) patients, treated at the Affiliated Hospital of North Sichuan Medical College from January 2016 to October 2023, prior to their first treatment. The HALP score was calculated, and the optimal cutoff value for HALP was determined using X-tile software. Survival analysis was performed using Kaplan-Meier curves for high HALP and low HALP groups. Univariate and multivariate analyses were conducted using the Cox regression model, and a forest plot was generated using Graphpad Prism to illustrate factors that may impact patient prognosis. The predictive ability of HALP score combined with β2-microglobulin and ECOG score for prognosis in MM patients was evaluated using receiver operating characteristic curve (ROC) analysis. [Results] A total of 203 MM patients were included, with the optimal cutoff value for HALP score being 29.15 (P<0.05). Among them, 101 patients were in the low HALP score group, and 102 patients were in the high HALP score group. The results of univariate and multivariate analysis using the Cox regression model showed that a HALP score <29.15 was an independent risk factor for progression-free survival (PFS) and overall survival (OS) (P<0.05). ROC curve analysis indicated that the combination of HALP score with β2-microglobulin and ECOG score had a higher predictive value for prognosis in MM patients compared to using HALP score alone. [Conclusion] The HALP score is closely related to the prognosis of patients with NDMM. A low HALP score indicates a poorer prognosis, while the combination of HALP score with β2-microglobulin and ECOG score provides a higher predictive value when assessed together.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.010&lang=enmultiple myelomaprognosishemoglobinlymphocytealbuminplatelet |
| spellingShingle | CHEN Min AN Liying LIN Xiaojing ZHAO Pan ZOU Xingli WEI Jin NI Xun Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy Zhongguo shuxue zazhi multiple myeloma prognosis hemoglobin lymphocyte albumin platelet |
| title | Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy |
| title_full | Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy |
| title_fullStr | Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy |
| title_full_unstemmed | Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy |
| title_short | Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy |
| title_sort | prognostic correlation analysis of multiple myeloma based on halp score of peripheral blood before chemotherapy |
| topic | multiple myeloma prognosis hemoglobin lymphocyte albumin platelet |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.010&lang=en |
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