Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer
Breast cancer, which arises from the epithelial tissue of the breast, is one of the most common cancers affecting women worldwide. Its incidence and mortality rates have been increasing in both developed and developing countries. As a hormone-dependent cancer, breast cancer is classified into severa...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325001184 |
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| author | Zhengjia Lu Tingrui Wang Lu Wang Jia Ming |
| author_facet | Zhengjia Lu Tingrui Wang Lu Wang Jia Ming |
| author_sort | Zhengjia Lu |
| collection | DOAJ |
| description | Breast cancer, which arises from the epithelial tissue of the breast, is one of the most common cancers affecting women worldwide. Its incidence and mortality rates have been increasing in both developed and developing countries. As a hormone-dependent cancer, breast cancer is classified into several molecular subtypes based on the expression of key markers: Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal Growth Factor Receptor 2 (HER-2), and Ki67. PR loss is associated with endocrine resistance and a poorer prognosis in breast cancer. Despite this, the underlying mechanisms of ER-positive/PR-negative (ER+PR-) breast cancer remain poorly understood. This study aims to review recent advancements in research on ER+PR- breast cancer, analyze its clinical characteristics and molecular mechanisms, and provide recommendations for more targeted therapeutic approaches. |
| format | Article |
| id | doaj-art-2d3b9c90b8a14a4f872e59f23d3c4a2c |
| institution | OA Journals |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-2d3b9c90b8a14a4f872e59f23d3c4a2c2025-08-20T02:14:38ZengElsevierTranslational Oncology1936-52332025-06-015610238710.1016/j.tranon.2025.102387Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancerZhengjia Lu0Tingrui Wang1Lu Wang2Jia Ming3Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaCorresponding author.; Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBreast cancer, which arises from the epithelial tissue of the breast, is one of the most common cancers affecting women worldwide. Its incidence and mortality rates have been increasing in both developed and developing countries. As a hormone-dependent cancer, breast cancer is classified into several molecular subtypes based on the expression of key markers: Estrogen Receptor (ER), Progesterone Receptor (PR), Human Epidermal Growth Factor Receptor 2 (HER-2), and Ki67. PR loss is associated with endocrine resistance and a poorer prognosis in breast cancer. Despite this, the underlying mechanisms of ER-positive/PR-negative (ER+PR-) breast cancer remain poorly understood. This study aims to review recent advancements in research on ER+PR- breast cancer, analyze its clinical characteristics and molecular mechanisms, and provide recommendations for more targeted therapeutic approaches.http://www.sciencedirect.com/science/article/pii/S1936523325001184Breast cancerEstrogen receptorProgesterone receptorEndocrine therapy |
| spellingShingle | Zhengjia Lu Tingrui Wang Lu Wang Jia Ming Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer Translational Oncology Breast cancer Estrogen receptor Progesterone receptor Endocrine therapy |
| title | Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer |
| title_full | Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer |
| title_fullStr | Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer |
| title_full_unstemmed | Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer |
| title_short | Research progress on estrogen receptor-positive/progesterone receptor-negative breast cancer |
| title_sort | research progress on estrogen receptor positive progesterone receptor negative breast cancer |
| topic | Breast cancer Estrogen receptor Progesterone receptor Endocrine therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325001184 |
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