Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System
The implementation of a laboratory information system (LIS) at the Hospital for Tropical Diseases in Thailand provides valuable medical resources, particularly for dengue. Hematocrit (Hct), which is often derived from hemoglobin (Hgb), is important in the diagnosis and management of dengue. This stu...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/8852031 |
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| author | Duangjai Sahassananda Vipa Thanachartwet Putza Chonsawat Benjamaporn Wongphan Supat Chamnanchanunt Manoon Surabotsophon Varunee Desakorn |
| author_facet | Duangjai Sahassananda Vipa Thanachartwet Putza Chonsawat Benjamaporn Wongphan Supat Chamnanchanunt Manoon Surabotsophon Varunee Desakorn |
| author_sort | Duangjai Sahassananda |
| collection | DOAJ |
| description | The implementation of a laboratory information system (LIS) at the Hospital for Tropical Diseases in Thailand provides valuable medical resources, particularly for dengue. Hematocrit (Hct), which is often derived from hemoglobin (Hgb), is important in the diagnosis and management of dengue. This study aimed to evaluate the Hct value obtained from the LIS automated analyzer. We prospectively enrolled 163 hospitalized adults with dengue, for whom 1,141 real-time complete blood count (CBC) results were obtained via a hematology analyzer and updated in the LIS database. The median (interquartile range (IQR)) duration of analytic turnaround times (TATs) was 40.0 (30.0–53.0) minutes. Linear regression analysis indicated a significant relationship between Hgb and Hct with a coefficient of determination (Pearson’s R2) of 0.92 at red blood cell distribution width (RDW) ≤18, but Pearson’s R2 decreased to 0.78 at RDW >18. The Hct calculated from the three-fold conversion method and from the analyzer had a Pearson’s R2 of 0.92. At Hgb <12 g/dl and ≥16 g/dl, a greater difference between the two Hct values was observed, with median (IQR) differences of −0.8% (−1.9%–0.2%) and 0.8% (−0.1%–1.7%), respectively (P value <0.05). In conclusion, the Hgb and Hct of patients with dengue were highly correlated at RDW ≤18. The Hct calculated from the three-fold conversion method and from the analyzer had an excellent relationship, except when the Hgb was <12 g/dl or ≥16 g/dl. Apart from routine CBC evaluation, the LIS could help for accurate data collection in clinical research and development. |
| format | Article |
| id | doaj-art-2d10c7d7c442446d925b1987c2420a57 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-2d10c7d7c442446d925b1987c2420a572025-02-03T06:46:16ZengWileyJournal of Tropical Medicine1687-96861687-96942021-01-01202110.1155/2021/88520318852031Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information SystemDuangjai Sahassananda0Vipa Thanachartwet1Putza Chonsawat2Benjamaporn Wongphan3Supat Chamnanchanunt4Manoon Surabotsophon5Varunee Desakorn6Information Technology Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandCenter Diagnostic Laboratory, Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandCenter Diagnostic Laboratory, Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandPulmonary and Critical Care Division, Department of Medicine, Ramkhamhaeng Hospital, Bangkok 10240, ThailandDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandThe implementation of a laboratory information system (LIS) at the Hospital for Tropical Diseases in Thailand provides valuable medical resources, particularly for dengue. Hematocrit (Hct), which is often derived from hemoglobin (Hgb), is important in the diagnosis and management of dengue. This study aimed to evaluate the Hct value obtained from the LIS automated analyzer. We prospectively enrolled 163 hospitalized adults with dengue, for whom 1,141 real-time complete blood count (CBC) results were obtained via a hematology analyzer and updated in the LIS database. The median (interquartile range (IQR)) duration of analytic turnaround times (TATs) was 40.0 (30.0–53.0) minutes. Linear regression analysis indicated a significant relationship between Hgb and Hct with a coefficient of determination (Pearson’s R2) of 0.92 at red blood cell distribution width (RDW) ≤18, but Pearson’s R2 decreased to 0.78 at RDW >18. The Hct calculated from the three-fold conversion method and from the analyzer had a Pearson’s R2 of 0.92. At Hgb <12 g/dl and ≥16 g/dl, a greater difference between the two Hct values was observed, with median (IQR) differences of −0.8% (−1.9%–0.2%) and 0.8% (−0.1%–1.7%), respectively (P value <0.05). In conclusion, the Hgb and Hct of patients with dengue were highly correlated at RDW ≤18. The Hct calculated from the three-fold conversion method and from the analyzer had an excellent relationship, except when the Hgb was <12 g/dl or ≥16 g/dl. Apart from routine CBC evaluation, the LIS could help for accurate data collection in clinical research and development.http://dx.doi.org/10.1155/2021/8852031 |
| spellingShingle | Duangjai Sahassananda Vipa Thanachartwet Putza Chonsawat Benjamaporn Wongphan Supat Chamnanchanunt Manoon Surabotsophon Varunee Desakorn Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System Journal of Tropical Medicine |
| title | Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System |
| title_full | Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System |
| title_fullStr | Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System |
| title_full_unstemmed | Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System |
| title_short | Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System |
| title_sort | evaluation of hematocrit in adults with dengue by a laboratory information system |
| url | http://dx.doi.org/10.1155/2021/8852031 |
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