Frequency modulation of ERK activation dynamics rewires cell fate

Frequency modulation of ERK activation dynamics rewires cell fate

Abstract Transient versus sustained ERK MAP kinase (MAPK) activation dynamics induce proliferation versus differentiation in response to epidermal (EGF) or nerve (NGF) growth factors in PC‐12 cells. Duration of ERK activation has therefore been proposed to specify cell fate decisions. Using a biosen...

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Bibliographic Details
Main Authors: Hyunryul Ryu, Minhwan Chung, Maciej Dobrzyński, Dirk Fey, Yannick Blum, Sung Sik Lee, Matthias Peter, Boris N Kholodenko, Noo Li Jeon, Olivier Pertz
Format: Article
Language:English
Published: Springer Nature 2015-11-01
Series:Molecular Systems Biology
Subjects:
cell fate decisions
ERK activity dynamics
FRET biosensor
single cell biology
signaling heterogeneity
Online Access:https://doi.org/10.15252/msb.20156458
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https://doi.org/10.15252/msb.20156458

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