Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses
Flaviviruses are arthropod-borne viruses primarily transmitted through the mosquito <i>Aedes aegypti</i> or <i>Culex</i> genus of mosquitos. These viruses are predominantly found in tropical and subtropical regions of the world with their geographical spread predicted to incr...
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MDPI AG
2024-12-01
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| author | Thomas J. Baric Z. Beau Reneer |
| author_facet | Thomas J. Baric Z. Beau Reneer |
| author_sort | Thomas J. Baric |
| collection | DOAJ |
| description | Flaviviruses are arthropod-borne viruses primarily transmitted through the mosquito <i>Aedes aegypti</i> or <i>Culex</i> genus of mosquitos. These viruses are predominantly found in tropical and subtropical regions of the world with their geographical spread predicted to increase as global temperatures continue to rise. These viruses cause a variety of diseases in humans with the most prevalent being caused by dengue, resulting in hemorrhagic fever and associated sequala. Current approaches for therapeutic control of flavivirus infections are limited, and despite recent advances, there are no approved drugs. Vaccines, available for a few circulating flaviviruses, still have limited potential for controlling contemporary and future outbreaks. Mouse models provide us with a valuable tool to test the effectiveness of drugs and vaccines, yet for many flaviviruses, well-established mouse models are lacking. In this review, we highlight the current state of flavivirus vaccines and therapeutics, as well as our current understanding of mouse models for various flaviviruses. |
| format | Article |
| id | doaj-art-2cb9a614335744d1b6a8b18dc0447e6e |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-2cb9a614335744d1b6a8b18dc0447e6e2025-01-24T13:52:12ZengMDPI AGViruses1999-49152024-12-01171110.3390/v17010001Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging FlavivirusesThomas J. Baric0Z. Beau Reneer1Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3500, USADepartment of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3500, USAFlaviviruses are arthropod-borne viruses primarily transmitted through the mosquito <i>Aedes aegypti</i> or <i>Culex</i> genus of mosquitos. These viruses are predominantly found in tropical and subtropical regions of the world with their geographical spread predicted to increase as global temperatures continue to rise. These viruses cause a variety of diseases in humans with the most prevalent being caused by dengue, resulting in hemorrhagic fever and associated sequala. Current approaches for therapeutic control of flavivirus infections are limited, and despite recent advances, there are no approved drugs. Vaccines, available for a few circulating flaviviruses, still have limited potential for controlling contemporary and future outbreaks. Mouse models provide us with a valuable tool to test the effectiveness of drugs and vaccines, yet for many flaviviruses, well-established mouse models are lacking. In this review, we highlight the current state of flavivirus vaccines and therapeutics, as well as our current understanding of mouse models for various flaviviruses.https://www.mdpi.com/1999-4915/17/1/1animal modelsdengue virusflavivirusPowassan virustick-borne encephalitis virusUsutu virus |
| spellingShingle | Thomas J. Baric Z. Beau Reneer Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses Viruses animal models dengue virus flavivirus Powassan virus tick-borne encephalitis virus Usutu virus |
| title | Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses |
| title_full | Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses |
| title_fullStr | Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses |
| title_full_unstemmed | Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses |
| title_short | Animal Models, Therapeutics, and Vaccine Approaches to Emerging and Re-Emerging Flaviviruses |
| title_sort | animal models therapeutics and vaccine approaches to emerging and re emerging flaviviruses |
| topic | animal models dengue virus flavivirus Powassan virus tick-borne encephalitis virus Usutu virus |
| url | https://www.mdpi.com/1999-4915/17/1/1 |
| work_keys_str_mv | AT thomasjbaric animalmodelstherapeuticsandvaccineapproachestoemergingandreemergingflaviviruses AT zbeaureneer animalmodelstherapeuticsandvaccineapproachestoemergingandreemergingflaviviruses |