Selective metabolic regulations by p53 mutant variants in pancreatic cancer

Selective metabolic regulations by p53 mutant variants in pancreatic cancer

Abstract Background Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progression. However, the clinical significance of p53 GOF...

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Main Authors: Sabrina Caporali, Alessio Butera, Alessia Ruzza, Carlotta Zampieri, Marina Bantula’, Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U. Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D’Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Tumour suppressor
Gain-of-function
Cancer Metabolism
Anti-oxidant capacity
Online Access:https://doi.org/10.1186/s13046-024-03232-3
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