Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice

Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice

Background: Chronic high-fat diet (HFD) feeding triggers hypothalamic inflammation and systemic metabolic dysfunction associated with endoplasmic reticulum (ER) stress. Glial cells, specifically microglia and astrocytes, are central mediators of hypothalamic inflammation. However, the role of Inosit...

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Bibliographic Details
Main Authors: L. Stilgenbauer, Q. Chen, D. Pungi, N. James, H. Jayarathne, L. Koshko, S. Scofield, K. Zhang, M. Sadagurski
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Molecular Metabolism
Subjects:
Hypothalamic inflammation
Microglia
Hypothalamus
ER stress
UPR
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000353
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