The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis

The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis

The mevalonate pathway plays an important role in breast cancer and other tumor types. However, many issues remain obscure as yet regarding its mechanism of regulation and action. In the present study, we report that the expression of mevalonate pathway enzymes is mediated by the RHO guanosine nucle...

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Bibliographic Details
Main Authors: Javier Conde, Isabel Fernández‐Pisonero, L. Francisco Lorenzo‐Martín, Rocío García‐Gómez, Berta Casar, Piero Crespo, Xosé R. Bustelo
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Molecular Oncology
Subjects:
cholesterol
guanosine nucleotide exchange factors
oncogenic signaling
RAC1
RHO GTPases
sterol regulatory element‐binding protein
Online Access:https://doi.org/10.1002/1878-0261.13716
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https://doi.org/10.1002/1878-0261.13716

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