Differential inhibitory effects of endocannabinoids on neuronal firing of mouse meningeal afferents

Differential inhibitory effects of endocannabinoids on neuronal firing of mouse meningeal afferents

Abstract Background Increasing endocannabinoids (endoCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG), through inhibition of the degrading hydrolase enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively, has been proposed as approach to alleviate migrain...

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Bibliographic Details
Main Authors: Georgii Krivoshein, Adriana Della Pietra, Juha Savinainen, Arn M. J. M. van den Maagdenberg, Rashid Giniatullin
Format: Article
Language:English
Published: BMC 2025-05-01
Series:The Journal of Headache and Pain
Subjects:
Migraine
Neuronal firing
Anandamide
2-arachidonoylglycerol
FAAH
MAGL
Online Access:https://doi.org/10.1186/s10194-025-02041-z
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