27-Hydroxycholesterol in cancer development and drug resistance

27-Hydroxycholesterol in cancer development and drug resistance

27-Hydroxycholesterol (27HC), a cholesterol metabolite, functions both as a selective oestrogen receptor (ER) modulator and a ligand for liver X receptors (LXRs). The discovery of 27HC involvement in carcinogenesis has unveiled new research avenues, yet its precise role remains controversial and con...

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Bibliographic Details
Main Authors: Yaxin Hou, Zhiguang Fu, Chenhui Wang, Paulina Kucharzewska, Yuan Guo, Sihe Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
27-Hydroxycholesterol
enzyme
metabolism
cancer development
drug resistance
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2507670
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https://www.tandfonline.com/doi/10.1080/14756366.2025.2507670

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