Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

Abstract Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacterial and viral infection, can further compromise mitochond...

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Main Authors: Jordyn J. VanPortfliet, Yuanjiu Lei, Muthumeena Ramanathan, Camila Guerra Martinez, Jessica Wong, Tim J. Stodola, Brian R. Hoffmann, Kathryn Pflug, Raquel Sitcheran, Stephen C. Kneeland, Stephen A. Murray, Peter. J. McGuire, Carolyn L. Cannon, A. Phillip West
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59907-8
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https://doi.org/10.1038/s41467-025-59907-8

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