Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model
The trans-vessel wall device (TW-device) is a new endovascular tool for precise and safe delivery of various payloads (cells, viral, modified RNA, chemotherapy, growth factors) in oncology and regenerative medicine. The twofold aim of this study was to assess cell engraftment and tumor growth using...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897251313678 |
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| author | Victoria Lövljung Mathias Waldén Mikael Sandell Peter Damberg Staffan Holmin Fabian Arnberg Sandor |
| author_facet | Victoria Lövljung Mathias Waldén Mikael Sandell Peter Damberg Staffan Holmin Fabian Arnberg Sandor |
| author_sort | Victoria Lövljung |
| collection | DOAJ |
| description | The trans-vessel wall device (TW-device) is a new endovascular tool for precise and safe delivery of various payloads (cells, viral, modified RNA, chemotherapy, growth factors) in oncology and regenerative medicine. The twofold aim of this study was to assess cell engraftment and tumor growth using the TW-device for endovascular transplantation and to evaluate its ability to directly access solid tumors. We used the VX2 model in the rabbit kidney to compare percutaneously implanted fresh VX2 cells with TW-device injections of cryopreserved VX2 cells. We demonstrated the feasibility of endovascular transplantation ( n = 7) of tumor cells, achieving a 57.1% engraftment rate despite cryopreservation, comparable with 70% for percutaneous delivery of fresh cells ( n = 10). Re-access using the TW-device was 100% successful ( n = 11) with super-selective intratumoral contrast administration without complications. In conclusion, endovascular transplantation of VX2 cells using the TW-device resulted in proliferating cell grafts in the rabbit kidney establishing functional proof that cells indeed survive handling, preparation, and device passage. We also show the TW-device is able to access solid tumor parenchyma allowing precise intraparenchymal administration.This proof-of-concept study open up possibilities for repeated direct parenchymal injections via the endovascular route in any hard to reach organ. |
| format | Article |
| id | doaj-art-2c1b25bcfd384225a7096d714909b012 |
| institution | Kabale University |
| issn | 1555-3892 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj-art-2c1b25bcfd384225a7096d714909b0122025-01-28T10:03:28ZengSAGE PublishingCell Transplantation1555-38922025-01-013410.1177/09636897251313678Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit ModelVictoria Lövljung0Mathias Waldén1Mikael Sandell2Peter Damberg3Staffan Holmin4Fabian Arnberg Sandor5Department of Neuroradiology, Karolinska University Hospital, Stockholm, SwedenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenMedTechLabs, Stockholm, SwedenKarolinska Experimental Research and Imaging Centre, Karolinska University Hospital, Stockholm, SwedenMedTechLabs, Stockholm, SwedenDepartment of Neuroradiology, Karolinska University Hospital, Stockholm, SwedenThe trans-vessel wall device (TW-device) is a new endovascular tool for precise and safe delivery of various payloads (cells, viral, modified RNA, chemotherapy, growth factors) in oncology and regenerative medicine. The twofold aim of this study was to assess cell engraftment and tumor growth using the TW-device for endovascular transplantation and to evaluate its ability to directly access solid tumors. We used the VX2 model in the rabbit kidney to compare percutaneously implanted fresh VX2 cells with TW-device injections of cryopreserved VX2 cells. We demonstrated the feasibility of endovascular transplantation ( n = 7) of tumor cells, achieving a 57.1% engraftment rate despite cryopreservation, comparable with 70% for percutaneous delivery of fresh cells ( n = 10). Re-access using the TW-device was 100% successful ( n = 11) with super-selective intratumoral contrast administration without complications. In conclusion, endovascular transplantation of VX2 cells using the TW-device resulted in proliferating cell grafts in the rabbit kidney establishing functional proof that cells indeed survive handling, preparation, and device passage. We also show the TW-device is able to access solid tumor parenchyma allowing precise intraparenchymal administration.This proof-of-concept study open up possibilities for repeated direct parenchymal injections via the endovascular route in any hard to reach organ.https://doi.org/10.1177/09636897251313678 |
| spellingShingle | Victoria Lövljung Mathias Waldén Mikael Sandell Peter Damberg Staffan Holmin Fabian Arnberg Sandor Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model Cell Transplantation |
| title | Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model |
| title_full | Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model |
| title_fullStr | Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model |
| title_full_unstemmed | Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model |
| title_short | Trans-Vessel Wall Cell Transplantation, Engraftment, and Tumor Access in the VX2 Rabbit Model |
| title_sort | trans vessel wall cell transplantation engraftment and tumor access in the vx2 rabbit model |
| url | https://doi.org/10.1177/09636897251313678 |
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