Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders
Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview of their applications in this field, offering an updated perspective on their potentia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/15/1/79 |
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| author | Emmanuel Ortega-Robles Benito de Celis Alonso Jessica Cantillo-Negrete Ruben I. Carino-Escobar Oscar Arias-Carrión |
| author_facet | Emmanuel Ortega-Robles Benito de Celis Alonso Jessica Cantillo-Negrete Ruben I. Carino-Escobar Oscar Arias-Carrión |
| author_sort | Emmanuel Ortega-Robles |
| collection | DOAJ |
| description | Advanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview of their applications in this field, offering an updated perspective on their potential for early diagnosis, disease monitoring, and therapeutic evaluation. Emerging MRI modalities such as neuromelanin-sensitive imaging, diffusion-weighted imaging, magnetization transfer imaging, and relaxometry provide sensitive biomarkers that can detect early microstructural degeneration, iron deposition, and connectivity disruptions in key regions like the substantia nigra. These techniques enable earlier and more accurate differentiation of movement disorders, including Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, Lewy body and frontotemporal dementia, Huntington’s disease, and dystonia. Furthermore, MRI provides objective metrics for tracking disease progression and assessing therapeutic efficacy, making it an indispensable tool in clinical trials. Despite these advances, the absence of standardized protocols limits their integration into routine clinical practice. Addressing this gap and incorporating these techniques more systematically could bring the field closer to leveraging advanced MRI for personalized treatment strategies, ultimately improving outcomes for individuals with movement disorders. |
| format | Article |
| id | doaj-art-2c12c07baa8a4947997f6745b2c0cb6a |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-2c12c07baa8a4947997f6745b2c0cb6a2025-01-24T13:25:54ZengMDPI AGBrain Sciences2076-34252025-01-011517910.3390/brainsci15010079Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement DisordersEmmanuel Ortega-Robles0Benito de Celis Alonso1Jessica Cantillo-Negrete2Ruben I. Carino-Escobar3Oscar Arias-Carrión4Unidad de Trastornos del Movimiento y Sueño, Hospital General Dr. Manuel Gea González, Calzada de Tlalpan 4800, Mexico City 14080, MexicoFacultad de Ciencias Físico Matemáticas, Benemérita Universidad Autónoma de Puebla, Puebla 72570, MexicoTechnological Research Subdirection, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, MexicoDivision of Research in Clinical Neuroscience, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, MexicoUnidad de Trastornos del Movimiento y Sueño, Hospital General Dr. Manuel Gea González, Calzada de Tlalpan 4800, Mexico City 14080, MexicoAdvanced magnetic resonance imaging (MRI) techniques are transforming the study of movement disorders by providing valuable insights into disease mechanisms. This narrative review presents a comprehensive overview of their applications in this field, offering an updated perspective on their potential for early diagnosis, disease monitoring, and therapeutic evaluation. Emerging MRI modalities such as neuromelanin-sensitive imaging, diffusion-weighted imaging, magnetization transfer imaging, and relaxometry provide sensitive biomarkers that can detect early microstructural degeneration, iron deposition, and connectivity disruptions in key regions like the substantia nigra. These techniques enable earlier and more accurate differentiation of movement disorders, including Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, Lewy body and frontotemporal dementia, Huntington’s disease, and dystonia. Furthermore, MRI provides objective metrics for tracking disease progression and assessing therapeutic efficacy, making it an indispensable tool in clinical trials. Despite these advances, the absence of standardized protocols limits their integration into routine clinical practice. Addressing this gap and incorporating these techniques more systematically could bring the field closer to leveraging advanced MRI for personalized treatment strategies, ultimately improving outcomes for individuals with movement disorders.https://www.mdpi.com/2076-3425/15/1/79magnetic resonance imagingmovement disordersParkinson’s diseaseneurodegeneration biomarkersneuroimagingearly diagnosis |
| spellingShingle | Emmanuel Ortega-Robles Benito de Celis Alonso Jessica Cantillo-Negrete Ruben I. Carino-Escobar Oscar Arias-Carrión Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders Brain Sciences magnetic resonance imaging movement disorders Parkinson’s disease neurodegeneration biomarkers neuroimaging early diagnosis |
| title | Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders |
| title_full | Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders |
| title_fullStr | Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders |
| title_full_unstemmed | Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders |
| title_short | Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders |
| title_sort | advanced magnetic resonance imaging for early diagnosis and monitoring of movement disorders |
| topic | magnetic resonance imaging movement disorders Parkinson’s disease neurodegeneration biomarkers neuroimaging early diagnosis |
| url | https://www.mdpi.com/2076-3425/15/1/79 |
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