Identification of Mycobacterium tuberculosis intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screen

Identification of Mycobacterium tuberculosis intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screen

ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a serious infectious disease posing significant global health challenges. A critical evolutionary feature of M.tb is its genome encoding a set of eukaryotic-like secretory proteins, which facilitate intracellular surviv...

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Main Authors: Weiyi Liu, Yingchao Wang, Jiayuan Zhao, Xinyue Zhang, Zihui Li, Hongyan Jia, Chuanzhi Zhu, Lanyue Zhang, Liping Pan, Zongde Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium tuberculosis
macrophage
CRISPR screen
eukaryotic-like secretory protein
virulence effector
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00767-25
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https://journals.asm.org/doi/10.1128/spectrum.00767-25

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