Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site

Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and dis...

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Main Authors: Marc D. Schwabenlander, Jason C. Bartz, Michelle Carstensen, Alberto Fameli, Linda Glaser, Roxanne J. Larsen, Manci Li, Rachel L. Shoemaker, Gage Rowden, Suzanne Stone, W. David Walter, Tiffany M. Wolf, Peter A. Larsen
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Prion
Subjects:
Cervid
chronic wasting disease
ecology
environment
genetics
transmission
Online Access:https://www.tandfonline.com/doi/10.1080/19336896.2024.2343298
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Summary:Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.
ISSN:1933-6896
1933-690X

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